研究業績 | 国立成育医療研究センター研究所成育遺伝研究部

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2019

Kimura Y, Shofuda T, Higuchi Y, Nagamori I, Oda M, Nakamori M, Onodera M, Kanematsu D, Yamamoto A, Katsuma A, Suemizu H, Nakano T, Kanemura Y, Mochizuki H. Human Genomic Safe Harbors and the Suicide Gene-Based Safeguard System for iPSC-Based Cell Therapy. Stem Cells Transl Med 2019 Mar 19. doi: 10.1002/sctm.18-0039.
Narumoto S, Sakamoto S, Sasaki K, Hirata Y, Fukuda A, Uchiyama T, Irie R, Yoshida T, Kasahara M. ABO-incompatible liver transplantation for children under 2 years of age: A case report and a single-center review. Pediatr Transplant 2019 23:e13308. doi: 10.1111/petr.13308.
Tsuchida M, Kirino Y, Soejima Y, Onodera M, Arai K, Tamura E, Ishikawa T, Kawai T, Uchiyama T, Nomura S, Kobayashi D, Taguri M, Mitsuhashi T, Takata A, Miyake N, Nakajima H, Miyake S, Matsumoto N. Haploinsufficiency of A20 caused by a novel nonsense variant or entire deletion of TNFAIP3 is clinically distinct from Behçet disease. Arthritis Res Ther 21: 137, 2019 doi: 10.1186/s13075-019-1928-5
Hosaka S, Kobayashi C, Saito H, Imai-Saito A, Suzuki R, Iwabuchi A, Kato Y, Jimbo T, Watanabe N, Onodera M, Imadome KI, Masumoto K, Nanmoku T, Fukushima T, Kosaki K, Sumazaki R, Takada H. Establishment of immunity against Epstein-Barr virus infection in a patient with CHARGE/complete DiGeorge syndrome after peripheral blood lymphocyte transfusion. Pediatr Transplant 23:e13424. 2019 doi: 10.1111/petr.13424.
Tomono T, Hirai Y, Chono H, Mineno J, Ishii A, Onodera M, Tamaoka A, Okada T. Infectivity Assessment of Recombinant Adeno-Associated Virus and Wild-Type Adeno-Associated Virus Exposed to Various Diluents and Environmental Conditions. Hum Gene Ther Methods 30: 137-143, 2019.
Kikuchi T, Nakae J, Kawano Y, Watanabe N, Onodera M, Itoh H. Foxo in T Cells Regulates Thermogenic Program through Ccr4/Ccl22. iScience 22: 81-96, 2019.
Ushijima K, Okuno M, Ayabe T, Kikuchi N, Kawamura T, Urakami T, Yokota I, Amemiya S, Uchiyama T, Kikuchi T, Ogata T, Sugihara S, Fukami M. Low prevalence of maternal microchimerism in peripheral blood of Japanese children with type I diabetes. Diabet Med doi: 1007/s12185-019-02795-8
Shirai R, Osumi T, Terashima K, Kiyotani C, Uchiyama M, Tsujimoto S, Yoshida M, Yoshida K, Uchiyama T, Tmizawa D, Shioda Y, Sekiguchi M, Watanabe K, Keino D, Ueno-Yokohata H, Ohki K, Takita J, Ito S, Deguchi T, Kiyokawa N, Ogiwara H, Hishiki T, Ogawa S, Okita H, Matsumoto K, Yoshioka T, Kato M. High prevalence of SMARCB1 constitutional abnormalities including mosaicism in malignant rhabdoid tumours. Eur J Hum Genet 2020 Mar 26. doi: 10.1038/s41431-020-0614-z.
Saito T, Ito Y, Samura O, Aoki H, Uchiyama T, Okamoto A, Hata K. Direct assessment of a single-cell DNA using crudely purified live cells: a proof of concept for noninvasive prenatal definitive diagnosis. J Mol Diagn 22: 132-140, 2020. doi: 10.1016/j.jmoldx.2019.10.006.
Tsujimoto SI, Shirai R, Utano T, Osumi T, Matsumoto K, Shioda Y, Kiyotani C, Uchiyama T, Deguchi T, Terashima K, Tomizawa D, Matsumoto K, Kato M. Comparison of clonazepam and levetiracetam in children for prevention of busulfan-induced seizure in hematopoietic stem cell transplantation. Int J Hematol 111: 463-466, 2020.
Ushijima K, Okuno M, Ayabe T, Kikuchi N, Kawamura T, Urakami T, Yokota I, Amemiya S, Uchiyama T, Kikuchi T, Ogata T, Sugihara S, Fukami M; Japanese Study Group of Insulin Therapy for Childhood and Adolescent Diabetes. Low prevalence of maternal microchimerism in peripheral blood of Japanese children with type 1 diabetes. Diabet Med 2019 Dec 23: doi: 10.1111/dme.14221.

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2018

Kamei K, Miyairi I, Ishikura K, Ogura M, Shoji K, Funaki T, Ito R, Arai K, Abe J, Kawai T, Onodera M, Ito S. Prospective Study of Live Attenuated Vaccines for Patients with Nephrotic Syndrome Receiving Immunosuppressive Agents. J Pediatr S0022-3476 (17) 31756-0, 2018.
Nishi K, Kawai T, Kubota M, Ishiguro A, Onodera M. X-linked agammaglobulinemia complicated with pulmonary aspergillosis. Pediatr Int 1: 90-92, 2018.
Osumi T, Tsujimoto S, Nakabayashi K, Taniguchi M, Shirai R, Yoshida M, Uchiyama T, Nagasawa J, Goyama S, Yoshida T, Tomizawa T, Kurokawa M, Matsubara Y, Kiyokawa N, Hata K, Kato M. Somatic MECOM mosaicism in a patient with congenital bone marrow failure without a radial abnormality. Pediatr Blood Cancer 65: e26959, 2018.
Tsujimoto S, Osumi T, Uchiyama M, Shirai R, Moriyama T, Nishii R, Yamada Y, Kudo K, Sekiguchi M, Arakawa Y, Yoshida M, Uchiyama T, KTerui, Ito S, Koh K, Takita J, Ito E, Tomizawa D, Manabe A, Kiyokawa N, Yang J, Kato M. Diplotype analysis of NUDT15 variants and 6-mercaptopurine sensitivity in pediatric lymphoid neoplasms. Leukemia 32: 2710-2714, 2018.
Okano T, Imai K……, Uchiyama T, ……, Morio T. Hematopoietic stem cell transplantation for progressive combined immunodeficiency and lymphoproliferation in Activated PI3K? syndrome type 1. J Allergy Clin Immunol 2018 (in press)
Osumi T, Tsujimoto S, Tamura M, Uchiyama M, Nakabayashi K, Okamura K, Toshida M, Tomizawa D, Watanabe A, Takahashi H, Hori T, Yamamoto S, Hamamoto K, Migita M, Ogata-Kawata H, Uchiyama T, Kizawa H, Ueno-Yokohata H, Shirai R, Seki M, Ohki K, Inukai T, Ogawa S, Kitamura T, Matsumoto K, Hata K, Kiyokawa N, Goyama S, Kato M. Recurrent RARB translocation in Acute Promyelocytic leukemia lacking RARA translocation. Cancer Res 78: 4452-4458, 2018.
Osumi T, Tomizawa D, Kawai T, Sako M, Inoue E, Takimoto T, Tamura E, Uchiyama T, Imadome KI, Taniguchi M, Shirai R, Yoshida M, Ando R, Tsumura Y, Fuji H, Matsumoto K, Shioda Y, Kiyotani C, Terashima K, Onodera M, Matsumoto K, Kato M. A prospective study of allogeneic transplantation from unrelated donors for chronic granulomatous disease with target busulfan-based reduced-intensity conditioning. Bone Marrow Transplant 2018 Jun 29. doi: 10.1038/s41409-018-0271-9
Shoji K, Kawai T, Onodera M, Tsutsumi Y, Nosaka S, Miyairi I. Multiple osteolytic lesions on the skull of a girl with Mendelian susceptibility to mycobacterial disease. Pediatr Int 60: 1043-1044, 2018.
Tomono T, Hirai Y, Okada H, Miyagawa Y, Adachi K, Sakamoto S, Kawano Y, Chono H, Mineno J, Ishii A, Shimada T, Onodera M, Tamaoka A, Okada T. Highly Efficient Ultracentrifugation-free Chromatographic Purification of Recombinant AAV Serotype 9. Mol Ther Methods Clin Dev 11: 180-190, 2018. 32:2710-2714, 2018.
Tsujimoto S, Osumi T, Uchiyama M, Shirai R, Moriyama T, Nishii R, Yamada Y, Kudo Km Sekiguchi M, Arakawa Y, Yoshida M, Uchiyama T, Terui K, Ito S, Koh K, Takita J, Tomizawa D, Manabe A, Kiyokawa N, N. Yang JJ, Kato M. Diplotype analysis of NUD15 variants and 6-mercaptopurine sensitivity in pediatric lymphoid neoplasms. Leukemia 32:2710-2714, 2018.
Narumoto S, Sakamoto S, Sasaki K, Hirata Y, Fukuda A, Uchiyama T, Irie R, Yoshioka T, Kasahara M. ABO-incompatible liver transplantation for children under 2 years of age: A case report and a single center review. Pediatr. Transplant doi: 10.1111/petr.13308. 2018.
小野寺雅史　原発性免疫不全症の遺伝子治療　医薬ジャーナル 54:59-66，2018.
小野寺雅史　遺伝子治療の新局面 - はじめに - 医学のあゆみ265: 323，2018.
内山徹　レトロウイルス、レンチウイルスベクター：特徴と作製法、最近の話題　医学のあゆみ265: 337，2018.
小野寺雅史　毛細血管拡張性運動失調症産科と婦人科 85:649-653，2018.
小野寺雅史　ヘモグロビン異常症に対する造血幹細胞遺伝子治療 - βサラセミナ、鎌状赤血球症 - 血液フロンティア 28:768-774，2018.

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2017

Okuno M, Kasahara Y, Onodera M, Takubo N, Okajima M, Suga S, Watanabe N, Suzuki J, Ayabe T, Urakami T, Kawamura T, Kikuchi N, Yokota I, Kikuchi T, Amemiya S, Nakabayashi K, Hayashi K, Hata K, Matsubara Y, Ogata T, Fukami M, Sugihara S. Nucleotide substitutions in CD101, the human homolog of a diabetes susceptibility gene in non-obese diabetic mouse, in patients with type 1 diabetes. Journal of Diabetes Investigation 8: 286-294, 2017.
Osumi T, Kato M. Ouchi-Uchiyama M, Tomizawa D, Kataoka K, Fuji Y, Seki M, TAkita J, Ogawa S, Uchiyama T, Ohki K, Kiyokawa N. Blastic transformation of juvenile myelomonocytic leukemia caused by the copy number gain of onocogenic KRAS. Pediatr Blood Cancer 64(9),2017.
Goto F, Uchiyama T, Nakazawa Y, Kawai T, Imai K, Onodera M. Persistent impairment of T cell regeneration in a patient with activated PI3K d syndrome. J Clin Immunol 2017
Igarashi Y, Uchiyama T, Minegishi T, Takahashi S, Watanabe N, Kawai T, Yamada M, Ariga T, Onodera M. Single cell-based vector tracing in patients with ADA-SCID treated with stem cell gene therapy. Mol Ther Methods Clin Dev 6:8-16,2017.
Kawamura F, Inaki M, Katafuchi A, Abe Y, Tsuyama N, Kurosu Y, Yanagi A, Higuchi M, Muto S, Yamaura T, Suzuki H, Noji H, Suzuki S, Yoshida MA, Sasatani M, Kamiya K, Onodera M, Sakai A. Establishment of induced pluripotent stem cells from normal B cells and inducing AID expression in their differentiation into hematopoietic progenitor cells. Sci Rep 7:1659,2017.
Nakazawa Y, Kawai T, Arai K, Tamura E, Uchiyama T, Onodera M. Fecal Calprotectin Rise in Chronic Granulomatous Disease-Associated Colitis. J Clin Immunol 37:741-743,2017.

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2016

Ichida Y, Utsunomiya Y, Onodera M: Effect of the linkers between the zinc fingers in zinc finger protein 809 on gene silencing and nuclear localization. BBRC 18;471:533-8, 2016.
Obayashi N, Arai K, Nakano N, Mizukami T, Kawai T, Yamamoto S, Shimizu H, Nunoi H, Shimizu T, Tang J, Onodera M: Leopard skin-like colonic mucosa: A novel endoscopic finding of chronic granulomatous disease-associated colits. J. Pediatr Gastroenteol Nutr 62: 56-59, 2016.
Ichida Y, Utsunomiya Y, Onodera M: The third to fifth zinc fingers play an essential role in the binding of ZFP809 to the MLV-derived PBS. BBRC 469: 490-494, 2016.
Choong CJ, Sasaki T, Hayakawa H, Yasuda T, Baba K, Hirata Y, Uesato S, Mochizuki H. A novel histone deacetylase 1 and 2 isoform-specific inhibitor alleviates experimental Parkinson's disease. Neurobiol Aging 37:103-16 2016.
Tomono T, Hirai Y, Okada H, Adachi K, Ishii A, Shimada T, Onodera M, Tamaoka A, Okada T: Ultracentrifugation-free chromatography-mediated large-scale purification of recombinant adeno-associated virus serotype 1 (rAAV1). Mol Ther Methods Clin Dev 3: 15058, 2016.
Nagaya M, Watanabe M, Kobayashi M, Nakano K, Arai Y, Asano Y, Takeishi T, Umeki I, Fukuda T, Yashima S, Takayanagi S, Watanabe N, Onodera M, Matsunari H, Umeyama K, Nagashima H. A transgenic-cloned pig model expressing non-fluorescent modified Plum. Journal of Reproduction and Development 62; 511-520, 2016.
Kawano Y, Nakae J, Watanabe N, Kikuchi T, Tateya S, Tamori Y, Kaneko M, Abe T, Onodera M, Itoh H. Colonic Pro-Inflammatory Macrophages Cause Insulin Resistance in an Intestinal Ccl2/Ccr2-Dependent Manner. Cell Metabolism 24: 295-310, 2016.
Hasegawa K, Yasuda T, Shiraishi C, Fujiwara K, Przedborski S, Mochizuki H, Yoshikawa K. Promotion of mitochondrial biogenesis by necdin protects neurons against mitochondrial insults. Nat Commun 14;7:10943, 2016
Ikawa Y, Uchiyama T, Jagadeesh GJ, Candotti F. The long terminal repeat negative control region is a critical element for insertion oncogenesis after gene transfer into hematopoietic progenys with Moloney murine leukemia viral vectors. Gene therapy 23:815-818. 2016.
Naiki Y, Miyado M, Horikawa R, Katsumata N, Onodera M, Pang S, Ogata T, Fukami M. Extra-adrenal induction of Cyp21a1 ameliorates systemic steroid metabolism in a mouse model of congenital adrenal hyperplasia. strong>Endocrine Journal 63: 897-904, 2016.

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2015

Nakazawa Y, Kawai T, Uchiyama T, Goto F, Watanabe N, Maekawa T, Ishigro A, Okuyama, T, Otsu M, Yamada M, Hershfield MS, Ariga T, Onodera M: Effects of enzyme replacement therapy on immune function in ADA deficiency patient. Clin Immunol 161: 391-393, 2015.
Ichida Y, Utsunomiya Y, Yasuda T, Nakabayashi K, Sato T, Onodera M: Functional domains of ZFP809 essential for nuclear localization and gene silencing. PLOS ONE 10: e0139274, 2015.
Ichida Y, Utsunomiya Y, Tomikawa J, Nakabayashi K, Sato T, Onodera M: Long time-course monitoring of ZFP809-mediated gene silencing in transgene expression driven by promoters containing MLV-derived PBS. Biosci Biotechnol Biochem 7:1-7, 2015.
Kawai T, Arai K, Harayama S, Nakazawa Y, Goto F, Maekawa T, Tamura E, Uchiyama T, Onodera M: Severe and Rapid Progression in Very Early-Onset Chronic Granulomatous Disease-Associated Colitis. J Clin Immunol 35: 583-588, 2015.
Yoshida W, Tomikawa J, Inaki M, Kimura H, Onodera M, Hata K, Nakabayashi K: An insulator element located at the cyclin B1 interacting protein 1 gene locus is highly conserved among mammalian species. PLOS ONE 10: e0131204, 2015.
Takeuchi Y, Takeuchi E, Ishida T, Onodera M, Nakauchi H, Otsu M: Curative haploidentical BMT in a murine model of X-linked chronic granulomatous disease. Int J Hematol 102: 111-120, 2015.
Watanabe M, Kobayashi1 M, Nagaya M, Matsunari H, Nakano K, Maehara M, Hayashida G, Takayanagi S, Sakai R, Umeyama K, Watanabe N, Onodera M, Nagashima H: Production of transgenic cloned pigs expressing the far-red fluorescent protein monomeric Plum. J. Reprod Dev 61: 169-177, 2015.
Otsu M, Yamada M, Nakajima S, Kida M, Maeyama Y, Hatano N, Toita N, Takezaki S, Okura Y, Kobayashi R, Matsumoto Y, Tatsuzawa , Tsuchida F, Kato S, Kitagawa M, Mineno J, Hershfield MS, Bali P, Candotti F, Onodera M, Kawamura N, Sakiyama Y, Ariga T: Treatment Outcomes in Two Japanese Adenosine Deaminase-Deficiency Patients Treated by Stem Cell Gene Therapy with No Cytoreductive Conditioning. J Clin Immunol 35: 384-398, 2015.

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2014

Akagi K, Kawai T, Watanabe N, Yokoyama M, Arai K, Harayama S, Oana S, Onodera M. A case of macrophage activation syndrome developing in a patient with chronic granulomatous disease-associated colitis. J Pediatr Hematol/Oncol 36:e169-e171, 2014.
Kawai T, Watanabe N, Yokoyama M, Nakazawa Y, Goto F, Uchiyama T, Higuchi M, Maekawa T, Tamura E, Nagasaka S, Hojo M, Onodera M. Interstitial Lung Disease with Multiple Microgranulomas in Chronic Granulomatous Disease.J Clin Immunol 34:933-40,2014.
Takeda K, Nakazawa Y, Komuro H, Yamamoto M, Shoji K, Morita K, Miyairi I, Katsuta T, Ohya Y, Ishiguro A, Onodera M. Augmentation of anti-tubercular therapy with interferon g in a patient with dominant partial interferon g. Clinical Immunology 151: 25-28, 2014.
Lai CY, Yamazaki S, Okabe M, Suzuki S, Maeyama Y, Iimura Y, Onodera M, Kakuta S, Iwakura Y, Nojima M, Otsu M, Nakauchi H: Stage-specific roles for Cxcr4 signaling in murine hematopoietic stem/progenitor cells in the process of bone marrow repopulation. Stem Cells 32:1929-1942,2014.
Onuki K, Sugiyama H, Ishige K, Kawamoto T, Ota T, Ariizumi S, Yamato M, Kadota S, Takeuchi K, Ishikawa A, Onodera M, Onizawa K, Yamamoto M, Miyoshi E, Shoda J: Expression of N-acetylglucosaminyltransferase V in the subserosal layer correlates with postsurgical survival of pathological tumor stage 2 carcinoma of the gallbladder. J Gastroenterol 49:702-714,2014.
Looi CY, Sasahara Y, Watanabe Y, Satoh M, Hakozaki I, Uchiyama M, Wong WF, Du W, Uchiyama T, Kumaki S, Tsuchiya S, Kure S. The open conformation of WASP regulates its nuclear localization and gene transcription in myeloid cells. Int Immunol 26:341-352 2014.

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2013

Kobayashi M, Watanabe M, Matsunari H, Nakao K, Kanai T, Hayashida G, Matsumura Y, Kuramoto M, Sakai R, Arai Y, Umeyama K, Watanabe N, Onodera M, Nagaya M, Nagashima H. 20 generation and characterization of transgenic-cloned pigs expressing the far-red fluorescent protein monomeric plum. Reprod Fertil Dev 26: 124-125, 2013.
Yamamoto R, Morita Y, Ooehara J, Hamanaka S, Onodera M, Rudolph KL, Ema H, Nakauchi H. Clonal analysis unveils self-renewing lineage-restricted progenitors generated directly from hematopoietic stem cells. Cell 154: 1112-1126, 2013.
Tomack J, Seiler K, Grützkau A, Grün JR, Onodera M, Melchers F, Tsuneto M. Ectopic runx1 expression rescues tal-1-deficiency in the generation of primitive and definitive hematopoiesis. PLoS One 8: e70116, 2013.
Hamanaka S, Ooehara Jun, Morita Y, Ema H, Takahashi S, Miyawaki A, Otsu M, Yamaguchi T, Onodera M, Nakauchi H. Generation of transgenic mouse line expressing Kusabira Orange throughout body, including erythrocytes, by random segregation of provirus method. BBRC 435: 586-591, 2013.
Kawai T, Watanabe N, Yokoyama M, Arai K, Oana S, Harayama S, Yasui K, Oh-ishi T, Onodera M. Thalidomide Attenuates Excessive Inflammation without Interrupting Lipopolysaccharide-driven Inflammatory Cytokine Production in Chronic Granulomatous Disease. Clinical Immunol 147: 122-128, 2013
Kitazawa H, Moriya K, Niizuma H, Kawano K, Saito-Nanjo Y, Uchiyama T, Rikiishi T, Sasahara Y, Sakamoto O, Setoguchi Y, Kure S.：Interstitial lung disease in two brothers with novel compound heterozygous ABCA3 mutations. Eur J Pediatr 172: 953-957, 2013.
Watanabe Y, Sasahara Y, Satoh M, Looi CY, Katayama S, Suzuki T, Ouchi M, Horino S, Moriya K, Nanjyo Y, Onuma M, Kitazawa H, Irie M, Niizuma H, Uchiyama T, Rikiishi T, Kumaki S, Minegishi M, Wada T, Yachie A, Tsuchiya S, Kure S. : A case series of CAEBV of children and young adults treated with reduced-intensity conditioning and allogeneic bone marrow transplantation: a single-center study. Eur J Haemarol 91: 242-248, 2013.
Horino S, Uchiyama T, So T, Nagashima H, Sun SL, Sato M, Asao A, Haji Y, Sasahara Y, Candotti F, Tsuchiya S, Kure S, Sugamura K, Ishii N. : Gene therapy model of X-linked severe combined immunodeficiency using a modified foamy virus vector. PLos One 8: e71594, 2013.
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2012

Kawano Y, Nakae J, Watanabe N, Fujisaka S, Iskandar K, Sekioka R, Hayashi Y, Tobe K, Kasuga M, Noda T, Yoshimura A, Onodera M, Itoh H: Loss of PDK1-Foxo1 signaling in myeloid cells predisposes to adipose tissue inflammation and insulin resistance. Diabetes 61: 1935-1948, 2012.
Imagawa T, Takei S, Umebayashi H, Yamaguchi K, Itoh Y, Kawai T, Iwata N, Murata T, Okafuji I, Miyoshi M, Onoe Y, Kawano Y, Kinjo N, Mori M, Mozaffarian N, Kupper H, Santra S, Patel G, Kawai S, and Yokota S: Efficacy, Pharmacokinetics, and Safety of Adalimumab in Pediatric Patients with Juvenile Idiopathic Arthritis in Japan. Clin Rheumatol 31: 1713-1721, 2012.
Kawai T, Nishikomori R, Izawa K, Murata Y, Tanaka N, Sakai, H Saito M, Yasumi T, Takaoka Y, Nakahata T, Mizukami T, Nunoi H, Kiyohara Y, Yoden A, Murata T, Sasaki, S Ito E, Akutagawa H, Kawai T, Imai C, Okada, S Kobayashi M, Heike T: Frequent somatic mosaicism of NEMO in T cells of patients with X-linked anhidrotic ectodermal dysplasia with immunodeficiency. Blood 119: 5458-5466, 2012．

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2011

Namba T, Mochizuki H, Suzuki R, Onodera M, Yamaguchi M, Namiki H, Shioda S, Seki T: Time-lapse imaging reveals symmetric division of GFAP-expressing progenitors for expansion of postnatal dentate granule neurons. PLoS ONE　6:e25303,2011.
Inaki M, Kato D, Utsugi T, Onoda F, Hanaoka F, Murakami Y: Genetic analyses using a mouse cell cycle mutant identifies magoh as a novel gene involved in Cdk regulation. Genes Cells　16:166-178,2011
Kawahara M, Chen J, Sogo T, Teng J, Otsu M, Onodera M, Nakauchi H, Ueda H, Nagamune T:Growth promotion of genetically modified hematopoietic progenitors using antibody/ c-Mpl chimera. Cytokine 55: 402-408, 2011.
Maeyama Y, Otsu M, Kubo S, Yamano T, Iimura Y, Onodera M, Kondo S, Sakiyama Y, Ariga T: Intracellular estrogen receptor-binding fragment associated antigen 9 exerts in vivo tumor promoting effects via its coiled-coil region. Int J Oncology 39: 41-49, 2011.
Fujisawa Y, Nabekura T, Kawachi Y, Otsuka F, Onodera M: Enforced ROR(gamma)t expression in haematopoietic stem cells increases regulatory T cell number, which reduces immunoreactivity and attenuates hypersensitivity in vivo. Asian Pac J Allergy Immunol 29: 86-93, 2011.
Kunishima S, Kashiwagi H, Otsu M, Takayam N, Eto K, Onodera M, Miyajima Y, Takamatsu Y, Suzumiya J, Matsubara K, Tomiyama Y, S Hidehiko: Heterozygous ITGA2B R995W mutation inducing a constitutive activation of the aIIbb3 receptor affects proplatelet formation and causes congenital macrothrombocytopenia. Blood117: 5479-5484, 2011.
Sugiyama H, Onuki K, Ishige K, Baba N, Ueda T, Matsuda S, Takeuchi K, Onodera M, Nakanuma Y, Yamato M, Yamamoto M, Hyodo I, Shoda J: Potent In Vitro and In Vivo Antitumor Activity of Sorafenib Against Human Intrahepatic Cholangiocarcinoma Cells. J Gastroenterol 46: 779-789, 2011.
Kawai T, Kusakabe H, Seki A, Kobayashi S, Onodera M: Osteomyelitis due to triethoprim/sulfamethoxazole-resistant Edwardsiella tarda infection in a patient with X-linked chronic granulomatous disease. Infection 39: 171-173, 2011.
Kawai T, Kusakabe H, Seki A, Kobayashi K, Onodera M: Osteomyelitis Due to Trimethoprim/Sulfamethoxazole-Resistant Edwardsiella tarda Infection in a Patient with X-linked Chronic Granulomatous Disease. Infection 39:171-173, 2011.

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2010

Tozuka Y, Kumon M, Wada E, Onodera M, Mochizuki H, Wada K: Material obesity impairs hippocampal BDNF production and spatial learning performance in young mouse offspring. Neurochem Int 57: 235-247, 2010.
Hirata Y Hamanaka S, Onodera M: Transactivation of the dopamine receptor 3 gene by a single provirus integration results in development of B cell lymphoma in transgenic mice generated from retrovirally transduced embryonic stem cells. Blood115: 3930-3938, 2010.
Miyamoto N, Tanaka R, Shimura H, Watanabe T, Mori H, Onodera M, Mochizuki H, Hattori N, Urabe T: Phosphodiesterase III inhibition promotes differentiation and survival of oligodendrocyte progenitors and enhances regeneration of ischemic white matter lesions in the adult mammalian brain. J Cereb Blood Flow Metab 30: 299-310, 2010.
Kobayashi H, Shimada Y, Ikegami M, Kawai T, Sakurai K, Urashima T, Ijima M, Fujiwara M, Kaneshiro K, Ohashi T, Eto Y, Ishigaki K, Osawa M, Kyosen SO, Ida H: Prognostic factors for the late onset Pompe disease with enzyme replacement therapy: From our experience of 4 cases including an autopsy case. Mol Genet Metab100: 14-19, 2010.

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2009

Tamase A, Muraguchi T, Naka K, Hoshii T, Ohmura M, Kinoshita M, Tanaka S, Shugo H, Ooshio T, Nakada M, Sawamoto K, Onodera M, Matsumoto K, Oshima M, Asano M, Saya H, Okano H, Suda T, Hamada J, Hirao A: Identification of tumor-initiating cells in a highly aggressive brain tumor using promoter activity of nucleostemin. Proc Natl Acad Sci USA 106: 17163-17168, 2009.
Sanada M, Suzuki T, Shih LY, Otsu M, Kato Mo, Yamazaki S, Tamura A, Honda H, Mamiko, Yanagimoto S, Kumano K, Oda H, Yamagata T, Takita Junko, Gotoh N, Nakazaki K, Kawamata N, Onodera M, Nobuyoshi M, Hayashi Y, Harada H, Kurokawa M, Chiba S, Mori1 H, Ozawa K, Omine M, Hirai H, Nakauchi H, Koeffler HP, Ogawa S: Gain-of-function of mutated c-Cbl tumour suppressor associated with myeloid neoplasms with 11q UPD. Nature 460: 904-908, 2009.
Okabe M, Otsu M, Ahn DH, Kobayashi T, Morita Y, Wakiyama Y, Onodera M, Eto K, Ema H, Nakauchi H. Definitive proof for direct reprogramming of hematopoietic cells to pluripotency. Blood 114: 1764-1767, 2009.
Miyamoto N, Tanaka R, Zhang N, Shimura H, Onodera M, Mochizuki H, Hattori N, Urabe T. Crucial role for pCREB signaling in the differentiation and survival of neural progenitors under chronic cerebral hypoperfusion.Neuroscience162: 525-536, 2009.
Horiuchi Y, Onodera M, Miyagawa Y, Sato B, Onda K, Katagiri YU, Okita H, Okada M, Otsu M, Kume A, Okuyama T, Fujimoto J, Kuratsuji T, Kiyokawa N: Kinetics and effect of integrin expression in human CD34+ cells during MLV-derived retroviral transduction using a recombinant fibronectin for stem cell gene therapy. Hum Gene Ther 20: 777-783, 2009.
Sogo T, Kawahara M, Ueda H, Otsu M, Onodera M, Nakauchi H, Nagamune T: T cell growth control using hapten-specific antibody/interleukin-2 receptor chimera. Cytokine46: 127-136, 2009.
Fujisawa Y, Nabekura T, Nakao T, Nakamura Y, Takahashi T, Kawachi Y, Otsuka F, Onodera M: The induction of tumor-specific CD4+ T cells via major histocompatibility complex class II is required to gain optimal anti-tumor immunity against B16 melanoma cell line in tumor immunotherapy using dendritic cells.Exp Dermatol 18: 396-403, 2009.
Kawai T and Malech HL: WHIM syndrome: congenital immune deficiency disease.Curr Opin Hemat16: :20-26, 2009.

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2008

Matsunari H, Onodera M, Tada N, Mochizuki H, Miyawaki A, Karasawa S, Kurome M, Nagashima H: Transgenic-cloned pigs systemically expressing red fluorescent protein, Kusabira-Orange. Cloning stem cells 10: 313-323, 2008.
Sanuki S, Kaneko S, Otsu M, Karasawa S, Miyawaki A, Nagasawa T, Nakauchi H, Onodera M: A new red fluorescent protein that allows efficient marking of murine hematopoietic stem cells. J Gene Med 10: 965-971, 2008.
Kamiya A, Kakinuma S, Onodera M, Miyajima A, Nakauchi H: Prospero-related homeobox 1 and liver receptor homolog 1 coordinately regulate long-term proliferation of murine fetal hepatoblasts. Hepatology48: 252-264, 2008.
Onodera M: Gene and cell therapy for relapsed leukemia after allo-stem cell transplantation. Front Biosci13: 3408-3414, 2008.

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2007

Nabekura T, Nagasawa T, Nakauchi H, Onodera M: An Immunotherapy Approach with Dendritic Cells Genetically Modified to Express the Tumor-Associated Antigen, HER2. Cancer Immunology, Immunotherapy57: 611-622, 2007.
Chiba T, Zheng YW, Kita K, Yokosuka O, Onodera M, Miyoshi H, Nakano M, Zen Y, Nakauchi H, Iwama A, Taniguchi H: Enhanced Self-Renewal Capability in Hepatic Stem/Progenitor Cells Drives Cancer Initiation.Gastroenterology 133: 937-950, 2007.
Oka N, Soeda A, Inagaki A, Onodera M, Maruyama H, Hara A, Kunisada T, Mori H, Iwama T: VEGF promotes tumorigenesis and angiogenesis of human glioblastoma stem cells. BBRC 360: 553-559, 2007.
Namba T, Mochizuki H, Onodera M, Namiki H, Seki T: Postnatal neurogenesis in hippocampal slice cultures: Early in vitro labeling of neural precursor cells leads to efficient neuronal production. J Neurosci Res 85: 1704-1712, 2007.
Nishinakamura H, Minoda Y, Saeki K, Koga K, Takaesu G, Onodera M, Yoshimura A, Kobayashi T: An RNA binding protein aCP-1 is involved in the STAT3-mediated suppression of NF-kB transcriptional activity. Int Immunol 19: 609-619, 2007.
Seki T, Namba T, Mochizuki H, Onodera M: Clustering, migration and neurite formation of neural precursor cells in the adult rat hippocampus. J Comp Neurol 502: 275-290, 2007.
Hamanaka S, Nabekura T, Otsu M, Yoshida H, Nagata M, Usui J, Takahashi S, Nagasawa T, Nakauchi H,Onodera M: Stable transgene expression in mice generated from retrovirally transduced embryonic stem cells. Mol Ther 15: 560-565, 2007.
Onodera M: Gene and cell therapy for relapsed leukemia after allo-stem cell transplantation. Gene Therapy 2007 (21st Century’s Center of Excellence Program of Japanese Ministry of Education and Science), 286-295, 2007.
Maruyama H, Watanabe S, Kimura T, Liang J, Nagasawa T, Onodera M, Aonuma K, Yamaguchi I: Granulocyte colony-stimulating factor prevents progression of monocrotaline-induced pulmonary arterial hypertension in rats. Circulation J 71: 138-143, 2007.
Kawai T, Choi U, Liu PC, Whiting-Theobald NL, Linton GF, Malech HL: Diprotin A infusion into nonobese diabetic/severe combined immunodeficiency mice markedly enhances engraftment of human mobilized CD34+ peripheral blood cells. Stem Cells Dev 16: 361-370, 2007.
Kawai T, Choi U, Cardwell L, DeRavin SS, Naumann N, Whiting-Theobald NL, Linton GF, Moon J, Murphy PM, Malech HL.: WHIM syndrome myelokathexis reproduced in the NOD/SCID mouse xenotransplant model engrafted with healthy human stem cells transduced with C-terminus-truncated CXCR4.　Blood. 109: 78-84, 2007.

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2006

Cao Y, Kamioka Y, Mochizuki N, Yokoi N, Seino S, Kobayashi T, Hino O, Hara K, Yonezawa K, Onodera M, Nakae J: Interaction of FoxO1 and TSC2 induces insulin resistance through activation of mTOR/p70S6K pathway. J. Bio. Chem 281: 40242-40251, 2006.
Sasaki T, Ikeda H, Sato M, Ohkuri T, Abe H, Kuroki M, Onodera M, Miyamoto M, Kondo S, Nishimura T: Antitumor activity of chimeric immunoreceptor gene-modified Tc1 and Th1 cells against autologous carcinoembryonic antigen-expressing colon cancer cells. Cancer Sci 97: 920-927, 2006.
Suzuki E, Tsutsumi A, Goto D, Matsumoto I, Ito S, Otsu M, Onodera M, Takahashi S, Sato Y, Sumida T: Gene transduction of tristetraprolin or its active domain reduces TNF-alpha production by Jurkat T cells.Int J Mol Med 17: 801-809, 2006.
Uchiyama T, Ishikawa Y, Onodera M, Sato M, Du W, Sasahara Y, Tanaka N, Sugamura K, Tsuchiya S, Kumaki S: Application of HSVtk suicide gene to X-SCID gene therapy: Ganciclovir treatment offsets gene corrected X-SCID B cells. BBRC 341: 391-398, 2006.
Nabekura T, Otsu M, Nagasawa T, Nakauchi H, Onodera M: Potent vaccine therapy with dendritic cells genetically modified by the retroviral vector GCDNsap. Mol Ther 13: 301-309, 2006.

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2005

Namba T, Mochizuki H, Onodera M, Mizuno Y, Namiki H, Seki T: The fate of neural progenitor cells expressing astrocytic and radial glial markers in the postnatal rat dentate gyrus. Eur J Neurosci 22:1928-1941, 2005.
Iseki H, Shimizukawa R, Sugiyama F, Kunita S, Iwama A, Onodera M, Nakauchi H, Yagami K: Parvovirus NS induces an epigenetic modification through histone acetylation in host genes and reverts tumor malignancy to benignancy. J Virol 79: 8886-8893, 2005.
Yoshimi K, Ren YR, Seki T, Yamada M, Hayakawa H, Ooizumi H, Onodera M, Saito Y, Murayama S, Okano H, Mizuno Y, Mochizuki H: Limited neurogenesis of substantia nigra in patients and animal models of Parkinson's disease. Annals of Neurology 58: 31-40, 2005.
Kaneko S, Nagasawa T, Nakauchi H, Onodera M: An in vivo assay for retrovirally transduced human peripheral T lymphocytes using non-obese diabetic/ severe combined immunodeficiency mice. Exp Hematol33: 35-41, 2005.
Kawai T, Choi U, Whiting-Theobald NL, Linton GF, Brenner S, Sechler JM, Murphy PM, Malech HL: :Enhanced function with decreased internalization of carboxy-terminus truncated CXCR4 responsible for WHIM syndrome. Exp Hematol 33: 460-468, 2005.

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2004

Ueno T, Fujiwara M, Tomiyama H, Onodera M, Takiguchi M: Reconstitution of anti-HIV effector functions of primary human CD8 T lymphocytes by transfer of HIV-specific ab TCR genes. Eur J Immunol 34: 3379-3388,2004.
Yagi H, Nomura T, Nakamura K, Yamazaki S, Kitawaki T, Hori S, Maeda M, Onodera M, Uchiyama T, Fujii S, Sakaguchi S: Crucial role of FOXP3 in the development and function of human CD25+CD4+ regulatory T cells. Int Immunol 16: 1643-1656, 2004.
Ishibashi S, Sakaguchi M, Kuroiwa T, Yamasaki M, Kanemura Y, Shizuko I, Shimazaki T, Onodera M, Okano H, Mizusawa H: Human neural stem/progenitor cells, expanded in long-term neurosphere culture, promote functional recovery after focal ischemia in Mongolian gerbils. J Neurosci Res 78: 215-223, 2004.
Tanaka R, Yamashiro K, Mochizuki Hideki, Cho N, Onodera M, Mizuno Y, Urabe T: Neurogenesis after transient global ischemia in the adult hippocampus visualized by improved retroviral vector. Stroke35:1454-1459, 2004.
Okada T, Caplen N. J, Ramsey W. J, Onodera M, Shimazaki K, Nomoto T, Ajalli R, Wildner O, Morris J, Kume A, Hamada H, R. Blaese M, Ozawa K: In situ generation of pseudotyped retroviral progeny by adenovirus-mediated transduction of tumor cells enhances the killing effect of HSV-tk suicide gene therapy in vitro and in vivo. J Gene Medicine 6: 288-299, 2004.
Onodera M: Delivery of genes to hematopoietic stem cells. Methods Mol Biol 246: 527-539. 2004.
Yamada M, Onodera M, Mizuno Y, and Mochizuki H: Neurogenesis in olfactory bulb identified by retroviral labeling in normal and MPTP-treated adult mice. Neuroscience 124: 173-181, 2004.
Sugihara E, Kanai M, Matsui A, Onodera M, Schwab M, Miwa M: Enhanced expression of MYCN leads to centrosome hyperamplification after DNA damage in neuroblastoma cells. Oncogene 23: 1005-1009, 2004.
Brenner S, Whiting-Theobald N, Kawai T, Linton GF, Rudikoff AG, Choi U, Ryser MF, Murphy PM, Sechler JM, Malech HL : CXCR4-transgene expression significantly improves marrow engraftment of cultured hematopoietic stem cells. Stem Cells. 22: 1128-33, 2004.

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